CytoViva’s Hyperspectral Microscopy technology incorporates patented high signal-to-noise optical microscopy with high spectral resolution hyperspectral imaging. This enables optical observation and quantitative spectral analysis of nanoscale samples in a wide range of biological and materials-based environments. In addition, hyperspectral microscopy can be used to confirm unique surface chemistry and functional groups added to nanomaterials. Finally, certain biologicals, such as bacteria and pathogens, can be optically observed, spectrally characterized and mapped in tissue and other environments. In all examples, no special fluorescent markers are required.
CytoViva’s hyperspectral imaging capability can also support other standard microscope imaging techniques such as reflected light, fluorescence and transmitted light brightfield, as well as, a macro level image analysis platform.
For application examples illustrating how researchers around the world are currently using CytoViva’s Hyperspectral Microscopy Technology, please see below.
Metallic Nanoparticles
- Confirming AuNP Cell and Tissue Uptake
- Optical Observation of Nanoparticles
- Mapping AuNPs in Live Epithelial Cells
- Tracking Gold Nanoparticles in the Circulatory System
- Differentiating Aggregating and Non-Aggregating AgNPs
- Differentiating AgNPs and AuNPs in Single Cell Culture
- Nanomaterials Embedded in PET Fiber
- Au Nanorod Identification in Tissue
- AuNP Cell and Tissue Uptake Observation and Spectral Confirmation
- Confirming AgNPs in Food Containment Systems and Textiles
- Evaluating Nanorod Characteristics
- Imaging 50nm AuNPs in Live Blood Cells
- Observing AgNP Bacterial Cell Interactions
Drug Delivery
- CytoViva Nano Drug Delivery White Paper
- FDA Nano Drug Delivery Poster
- Lipid Nano Carriers & Hyperspectral Imaging
- Tracking Biopolymeric Nanoparticles in Cells
- Doxorubicin in Cancer Cells
- Tracking Free Drug ex vivo in Tissue
- Tracking Liposomal Drugs in Prostate Cancer Cells
- Identifying Functional Groups on Nanoparticles Used as Drug Delivery Agents
- Tracking Unlabeled Copolymer Nanovectors in Tissue
CNTs
Pathogen Detection
- Characterizing and Mapping Bacteria in Plant Tissue
- Identifying Different Strains of Bacillus
- Hyperspectral Characterization of Plant Pathogenic Organisms
Metal Oxides
- Tracking Iron Oxide Nanoparticles in Macrophages
- Nanoparticle Tracking in Whole animal organisms
- Silicon Wafer Doping Detection
- Simultaneous Observation of Nanoparticles and Fluorescent Labeled Cells
- Spectrally Mapping Fe2O3 Nanoparticles in Stained Tissue
General
- Finding Nanoparticles Dispersed in Cells
- High Throughput Nanoparticle Cell Interaction Microscopy
- How Optical Microscopy is Changing Nanotechnology Research
- Hyperspectral Microscopy Cross-Validated with Electron Microscopy and Raman Spectroscopy
- Label Free Nanoparticle Imaging in Cells
- Mapping Nanomaterials Dispersed in Plant Tissue
- Non-fluorescent Nanoparticle Observation in Cells and Tissue
- Observing Nanoparticle Interactions in Real Time
Special Interest
References
CytoViva Reference Bibliographies
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